Anti-Ubiquitin Antibody [ST46-03]

HUABIO

Anti-Ubiquitin Antibody [ST46-03]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

ST46-03

1 mg/ml

Unconjugated

RPS27A

ribosomal protein S27a

CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80, eS31, ubiquitin-ribosomal protein eS31 fusion protein, 40S ribosomal protein S27a, epididymis luminal protein 112, ubiquitin C, ubiquitin and ribosomal protein S27a, ubiquitin carboxyl extension protein 80, ubiquitin-40S ribosomal protein S27a, ubiquitin-CEP80

Rabbit

IgG

Polyubiquitin-B

Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway. Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. This antibody reacts with ubiquitin, a polypeptide w/ Mr. of approx. 8.5kD. It reacts with physiologically occurring conjugates of ubiquitin and intracellular proteins. Specifically recognizes ubiquitinated cytoplasmic inclusion bodies.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161