Anti-USP21 Antibody [16E1]

HUABIO

Anti-USP21 Antibody [16E1]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Monoclonal

16E1

2 mg/ml

Unconjugated

USP21

ubiquitin specific peptidase 21

USP16, USP23, ubiquitin carboxyl-terminal hydrolase 21, NEDD8-specific protease, deubiquitinating enzyme 21, ubiquitin specific protease 21, ubiquitin thioesterase 21, ubiquitin thiolesterase 21, ubiquitin-specific processing protease 21, ubiquitin-specific protease 16

Mouse

IgG1

Ubiquitin carboxyl-terminal hydrolase 21

USP21 (Ubiquitin Specific Peptidase 21) is a Protein Coding gene. Diseases associated with USP21 include Neurodevelopmental Disorder With Spasticity And Poor Growth. Among its related pathways are TNF signaling (REACTOME) and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and cysteine-type peptidase activity. An important paralog of this gene is USP2. Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at Lys-4, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161