Bio-Connect

anti-VASP (human), pAb

Research Use Only
AG-25T-0112
AdipoGen Life Sciences
ApplicationsImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetVASP
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-VASP (human), pAb
  • Delivery Days Customer
    10
  • Antibody Specificity
    Recognizes both the 46kDa (Ser157 dephospho-) and 50kDa (Ser157 phospho-) form of human VASP. Does not cross-react with mouse or rat VASP.
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Formulation
    Liquid
  • Gene ID7408
  • Target name
    VASP
  • Target description
    vasodilator stimulated phosphoprotein
  • Target synonyms
    vasodilator-stimulated phosphoprotein
  • Host
    Rabbit
  • Protein IDP50552
  • Protein Name
    Vasodilator-stimulated phosphoprotein
  • Scientific Description
    Polyclonal Antibody. Recognizes both the 46kDa (Ser157 dephospho-) and 50kDa (Ser157 phospho-) form of human VASP. Does not cross-react with mouse or rat VASP. Source: Rabbit. Applications: ICC, IP, WB. Liquid. Crude serum containing 0.02% sodium azide. VASP (vasodilator-stimulated phosphoprotein) is a proline-rich protein substrate of cAMP- and cGMP-dependent protein kinases. VASP is an actin-associated protein involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping proteins. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments and it plays a role in actin-based mobility of Listeria monocytogenes in host cells. It regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. VASP phosphorylation is used to monitor the effect of so-called antiplatelet drugs that reduce platelet reactivity and are used to prevent stent thrombosis, strokes and heart attacks in patients. Phosphorylation of VASP at Ser157 causes a mobility shift in SDS gel electrophoresis from 46 to 50kDa, which has been used as a convenient marker to monitor cyclic nucleotide-dependent protein kinase activity. - VASP (vasodilator-stimulated phosphoprotein) is a proline-rich protein substrate of cAMP- and cGMP-dependent protein kinases. VASP is an actin-associated protein involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping proteins. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments and it plays a role in actin-based mobility of Listeria monocytogenes in host cells. It regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. VASP phosphorylation is used to monitor the effect of so-called antiplatelet drugs that reduce platelet reactivity and are used to prevent stent thrombosis, strokes and heart attacks in patients. Phosphorylation of VASP at Ser157 causes a mobility shift in SDS gel electrophoresis from 46 to 50kDa, which has been used as a convenient marker to monitor cyclic nucleotide-dependent protein kinase activity.
  • Reactivity
    Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203