Anti-VCAM1 Rabbit mAb

PTM BIO

Anti-VCAM1 Rabbit mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

JRMR-10855-28

Unconjugated

Rabbit

IgG

Vascular cell adhesion protein 1

VCAM-1 is a transmembrane glycoprotein containing multiple amino-terminal extracellular Ig-like domains, a transmembrane domain, and a short carboxy-terminal cytoplasmic domain. Alternative splicing generates two isoforms of VCAM-1. The role of VCAM-1 during infection and inflammatory diseases is well characterized. Expression of VCAM-1 is induced in endothelial cells by inflammatory cytokines including TNF-alfa and IL-1bèta. VCAM-1 on endothelial cells interacts with the integrin VLA-4 (alfa4bèta1) on leukocytes to mediate migration of circulating leukocytes from the blood across the endothelium and into tissues.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203