Anti-VISTA Rabbit mAb

PTM BIO

Anti-VISTA Rabbit mAb

5

Western Blot

WB

Research Use Only

Monoclonal

Unconjugated

Rabbit

IgG

V-type immunoglobulin domain-containing suppressor of T-cell activation

VISTA is a negative checkpoint control protein that regulates T cell activation and immune responses. VISTA, which contains a single Ig-like V-type domain, a transmembrane domain, and an intracellular domain, has sequence similarity to both the B7 and CD28 family members. Although primarily expressed by myeloid cells, VISTA is also expressed by CD4+, CD8+, and FoxP3+ T-cells. Thus, VISTA is described as both a ligand and a receptor. Blocking VISTA induces T-cell activation and proliferation, and potentiates disease severity in the EAE model. Furthermore, genetic deletion of VISTA in mice leads to spontaneous T-cell activation and chronic inflammation. In mouse models of cancer, neutralization of VISTA enhances T-cell proliferation and effector function and increases tumor infiltration, suggesting VISTA blockade could be an effective strategy for tumor immunotherapy.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse

Human, Mouse

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203