Anti-VP1 protein [NEG447A]

Absolute Antibody

Anti-VP1 protein [NEG447A]

9

This antibody binds the VP1 protein of the BK virus (Human polyomavirus 1). Polyomaviruses are icosahedral, non-enveloped, double-stranded DNA viruses. They measure 40-45 nm in diameter and are comprised of 88% protein and 12% DNA. Infection with the huma

This clone can be used for the detection of BK virus in a sample via ELISA. This clone is derived from P165E2 and has ~3-fold greater affinity and ~8-fold more potent activity (EC90) on serotype II, ~10-fold greater affinity for serotype IV than the parental clone. The parental clone P165E2, binds all four serotypes of BKV but cannot recognize denatured VP1 in western blot. Binding of the antibody is affected with mutations F66A, I145A, K69A and E82A in the VP1 protein (US9862760).

ELISA

Research Use Only

Monoclonal

NEG447A

Rabbit

IgG

Major capsid protein VP1

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Virus

-20°C,2°C to 8°C

12352203