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AKT1 antibody - Overexpression, IP/MS Validated

Catalog number: GTX110613100
Brand: GeneTex
Packing: 100 ul
Other sizes: Other size available
Price: On Request
Expected delivery time: 10 days
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GTX110613 ICC/IF Image
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Product specifications for - AKT1 antibody - Overexpression, IP/MS Validated

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; ImmunoPrecipitation; Western Blot
Species: Human, Mouse
Host: Rabbit
Target: AKT1
Target description: AKT serine/threonine kinase 1
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Controle: HA-AKT transfected HeLa cell , mouse liver
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 0.47 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
Gene ID: 207
Swiss prot ID: P31749
Additional information: 
Synonyms: GTX_citation; GTX110613; AKT; AKT1m; CWS6; PKB; PKB alpha; PKB-ALPHA; PRKBA; Protein kinase B; protein kinase B alpha; proto-oncogene c-Akt; RAC; rac protein kinase alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1
A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine. Lee KH et al., 2014 Sep 17, Sci Rep Read more
A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat Methods Read more
Copanlisib, a novel phosphoinositide 3-kinase inhibitor, combined with carfilzomib inhibits multiple myeloma cell proliferation. Okabe S et al., 2019 Mar, Ann Hematol Read more
Erythropoietin protects neuroblastoma cells against etoposide and vincristine by activating ERK and AKT pathways but has no effect in kidney cells. Vazquez-Mellado MJ et al., 2015 Sep 15, Life Sci Read more
MicroRNA-296 inhibits colorectal cancer cell growth and enhances apoptosis by targeting ARRB1-mediated AKT activation. Zhang Z et al., 2019 Jan, Oncol Rep Read more
MicroRNA-296 inhibits colorectal cancer cell growth and enhances apoptosis by targeting ARRB1-mediated AKT activation. Zhang Z et al., 2019 Jan, Oncol Rep Read more
The synthetic flavonoid WYC02-9 inhibits cervical cancer cell migration/invasion and angiogenesis via MAPK14 signaling. Chen YJ et al., 2013 Dec, Gynecol Oncol Read more
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