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ProductsBack/Antileishmanial agent-19

Antileishmanial agent-19

HY-155520

Molecular Weight386.40

Product group Chemicals

Overview

Supplier
MedChem Express
Product Name
Antileishmanial agent-19
Delivery Days Customer
14
Certification
Research Use Only
Molecular Formula
C22H18N4O3
Molecular Weight
386.40
Scientific Description
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 microM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals[1].
SMILES
O=C(NC1=NC=CC=C1)COC2=CC=C(C(N3C)=NC4=C(C=CC=C4)C3=O)C=C2
UNSPSC
12352200

MSDS

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