Antileishmanial agent-19
T79449
Molecular Weight386.4
Product group Chemicals
Overview
- SupplierTargetMol Chemicals
- Product NameAntileishmanial agent-19
- Delivery Days Customer999
- CertificationResearch Use Only
- Chemical NameAntileishmanial agent-19
- Molecular FormulaC22H18N4O3
- Molecular Weight386.4
- Scientific DescriptionCompound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 microM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and disrupting the host PI3K/Akt/CREB axis-mediated IL-10 secretion. Additionally, Compound F27 promotes autophagy-mediated apoptosis in L. donovani promastigotes and has been shown to reduce parasite burden in L.d-infected animals [1].
- Shelf life instruction3 years
- Storage Instruction-20°C
- UNSPSC12352200