Antimalarial agent 11 [1214454-56-4]

MedChem Express

Antimalarial agent 11 [1214454-56-4]

10

1214454-56-4

Research Use Only

C25H25F2NO3

425.47

Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 microM and 1.81 microM against D6 and ARC08-022 strains, respectively[1].

OC(CN1CCC2(CC(O)C3=C(O2)C4=C(C=CC=C4)C=C3)CC1)C5=CC=C(F)C(F)=C5

12131703