Antimalarial agent 23

MedChem Express

Antimalarial agent 23

10

Research Use Only

C24H23ClF3N5O

489.92

Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 microM and 0.10 microM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent beta-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin[1].

CCN(CC1=C(C=C(C=C1)Cl)O)CCNC2=NC=C3N=C(NC3=C2)C4=CC=CC(C(F)(F)F)=C4

12131703