Antioxidant agent-8

MedChem Express

Antioxidant agent-8

10

Research Use Only

C13H12O5

248.23

Antioxidant agent-8 is an orally active inhibitor of Abeta1-42 deposition. Antioxidant agent-8 inhibits fibril aggregation (IC50=11.15 microM) and promotes fibril disaggregation (IC50=6.87 microM). Antioxidant agent-8 also inhibits Cu2+-induced Abeta1-42 fibril aggregation (IC50=3.69 microM) and promotes Cu2+-induced Abeta1-42 fibril disaggregation (IC50=3.35 microM). Antioxidant agent-8 has antioxidant activity, anti-inflammatory activity, biosafety, blood-brain barrier permeability and neuroprotective effect[1].

O=C1CCOC(/C=C/C2=CC=C(C(O)=C2)O)=C1O

12131703