Antiparasitic agent-15

MedChem Express

Antiparasitic agent-15

10

Research Use Only

C17H16N4OS

324.40

Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC 50 s of 0.9 microM and 0.64 microM against trypomastigote and amastigote forms of T. cruzi . Antiparasitic agent-15 has IC 50 s of 42.2 microM and 9.58 microM against trypomastigote and amastigote forms of L. amazonensis . Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes [1] .

CC1(S/C(N(C1=O)C2=CC=CC=C2)=N/N=C/C3=CC=CC=N3)C

12352200