Antiparasitic agent-16

MedChem Express

Antiparasitic agent-16

10

Research Use Only

C18H18N4OS

338.43

Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC50s of 1.0 microM and 0.6 microM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC50s of 150.2 microM and 16.75 microM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes[1].

CC(C1S/C(N(C1=O)C2=CC=CC=C2)=N/N=C/C3=CC=CC=N3)C

12131703