Antiproliferative agent-57

MedChem Express

Antiproliferative agent-57

9

Research Use Only

C34H37ClN4O9

681.13

Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor. Antiproliferative agent-57 inhibits the secretion of VEGF in SiHa cells under hypoxic conditions (IC50=0.68 microM) without inducing cytotoxicity. Antiproliferative agent-57 can modulate the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells to inhibit the expression of HIF-1alpha and VEGF in tumor tissues[1].

COC(C1=CC[C@@]2(C(O[C@](C)(/C=C/C=C(C)/C(OCC(NCC3=CN(C4=CC=C(Cl)C=C4)N=N3)=O)=O)[C@]5([H])CC2)=O)[C@]5(OC(C)=O)CC1)=O

12352200