Antitrypanosomal agent 6

MedChem Express

Antitrypanosomal agent 6 [2492436-35-6]

10

Research Use Only

C22H29Cl2N5O

450.40

Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 microM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1].

CCN(CCOC1=CC=C(C2=NC3=CC(C4=NCCN4)=CC=C3N2)C=C1)CC.[H]Cl.[H]Cl

12131703