AP 18 [55224-94-7]

TargetMol Chemicals

AP 18 [55224-94-7]

9

55224-94-7

Chemical

Research Use Only

AP 18

0.9

C11H12ClNO

209.67

AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 microM Cinnamaldehyde with an IC50 of 3.1 microM and 4.5 microM for human and mouse TRPA1, respectively. AP-18 could reverse complete Freunds adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 microM AITC in a concentration-dependent manner (IC50= 10.3 microM).

3 years

C\C(=C/c1ccc(Cl)cc1)\C(\C)=N\O

-20°C

12352200