AP23464 [845895-51-4]
HY-10638
CAS Number845895-51-4
Product group Chemicals
Molecular Weight475.52
Overview
- SupplierMedChem Express
- Product NameAP23464 [845895-51-4]
- Delivery Days Customer9
- CAS Number845895-51-4
- CertificationResearch Use Only
- Molecular FormulaC26H30N5O2P
- Molecular Weight475.52
- Scientific DescriptionAP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells[1].
- SMILESO=P(C)(C)C1=CC=C(NC2=NC(C3CCCC3)=NC4=C2N=CN4CCC5=CC(O)=CC=C5)C=C1
- UNSPSC12352200