Apafant [105219-56-5]

MedChem Express

Apafant [105219-56-5]

10

105219-56-5

Research Use Only

99.96

C22H22ClN5O2S

455.96

Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, alpha-globin, beta-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit[1][2][3].

O=C(N1CCOCC1)CCC(S2)=CC3=C2N4C(CN=C3C5=CC=CC=C5Cl)=NN=C4C

-20°C,2°C to 8°C

12352200