APC Anti-Mouse CD150 Antibody

Reddot Biotech

APC Anti-Mouse CD150 Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

TC15-12F12.2

0.2 mg/ml

APC

Slamf1

signaling lymphocytic activation molecule family member 1

4933415F16; AA177906; CD150; CDw150; ESTM5; ESTM51; IP; IPO-3; S; signaling lymphocyte activation molecule; signaling lymphocytic activation molecule; Slam; SLAM family member 1

Rat

IgG2a

CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-Oe≥ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.

Mouse

2°C to 8°C

12352203