Apcin [300815-04-7]

AdipoGen Life Sciences

Apcin [300815-04-7]

10

300815-04-7

Research Use Only

>98%

C13H14Cl3N7O4

438.7

Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition. - Chemical. CAS: 300815-04-7. Formula: C13H14Cl3N7O4. MW: 438.7. Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.

CC1=NC=C(N1CCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl)[N+]([O-])=O

2°C to 8°C,-20°C

12352200