![Chemical Structure Chemical Structure](https://adipogen.com/pub/media/catalog/product/a/g/ag-cr1-3603_apcin.png)
Chemical Structure
Apcin [300815-04-7]
![Research Use Only](static/images/certificates/ruo.jpg)
AG-CR1-3603
CAS Number300815-04-7
Product group Chemicals
Estimated Purity>98%
Molecular Weight438.7
Overview
- SupplierAdipoGen Life Sciences
- Product NameApcin [300815-04-7]
- Delivery Days Customer10
- CAS Number300815-04-7
- CertificationResearch Use Only
- Estimated Purity>98%
- Molecular FormulaC13H14Cl3N7O4
- Molecular Weight438.7
- Scientific DescriptionCell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition. - Chemical. CAS: 300815-04-7. Formula: C13H14Cl3N7O4. MW: 438.7. Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.
- SMILESCC1=NC=C(N1CCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl)[N+]([O-])=O
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200
References
- Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C: K.L. Sackton, et al.; Nature 514, 646 (2014)