APE1 blocking peptide

GeneTex

APE1 blocking peptide

9

Research Use Only

APEX1

apurinic/apyrimidinic endodeoxyribonuclease 1

APE, APE1, APEN, APEX, APX, HAP1, REF1, DNA repair nuclease/redox regulator APEX1, AP endonuclease class I, AP lyase, APEX nuclease (multifunctional DNA repair enzyme) 1, DNA-(apurinic or apyrimidinic site) endonuclease, DNA-(apurinic or apyrimidinic site) lyase, apurinic-apyrimidinic endonuclease 1, apurinic/apyrimidinic (abasic) endonuclease, deoxyribonuclease (apurinic or apyrimidinic), protein REF-1, redox factor-1

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

-20°C or -80°C,2°C to 8°C

41116100

Human