APEX1 Polyclonal Antibody

Elabscience

APEX1 Polyclonal Antibody

12

Western Blot

ELISA WB IHC

Research Use Only

Polyclonal

0.1 mg/ml

Unconjugated

APEX1

apurinic/apyrimidinic endodeoxyribonuclease 1

APE, APE1, APEN, APEX, APX, HAP1, REF1, DNA repair nuclease/redox regulator APEX1, AP endonuclease class I, AP lyase, APEX nuclease (multifunctional DNA repair enzyme) 1, DNA-(apurinic or apyrimidinic site) endonuclease, DNA-(apurinic or apyrimidinic site) lyase, apurinic-apyrimidinic endonuclease 1, apurinic/apyrimidinic (abasic) endonuclease, deoxyribonuclease (apurinic or apyrimidinic), protein REF-1, redox factor-1

Rabbit

IgG

DNA repair nuclease/redox regulator APEX1

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

-20°C

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