API-1

MedChem Express

API-1 [36707-00-3]

10

36707-00-3

Research Use Only

99.62

C13H15N5O6

337.29

API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC 50 of ~0.8 microM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL) [1] [2] .

O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=NC=NC(N)=C3C(C(C(N)=O)=C2)=O

-20°C,2°C to 8°C

12352200