Apitolisib (GDC-0980)

Selleck Chemicals

Apitolisib (GDC-0980) [1032754-93-0]

9

Research Use Only

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Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kalpha/beta/delta/gamma with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.

-80°C

51202000