Apotransferrin, Dog [11096-37-0]

Athens Research

Apotransferrin, Dog [11096-37-0]

9

ELISA, Antigen for Antibody production, IVD Antigens, Calibrators & Controls, Protein Chemistry Research, Drug Delivery research

11096-37-0

Research Use Only

≥95% by SDS-PAGE

Apotransferrin, the iron-free form of the glycoprotein transferrin, serves as a critical regulator of systemic iron homeostasis by binding and transporting ferric ions (Fe³⁺) through plasma via a pH-dependent mechanism. It exhibits a structure with two iron-binding sites. Beyond its primary role in iron distribution, apotransferrin modulates immune function by sequestering free iron to limit microbial growth and directly suppresses proinflammatory cytokine production in autoimmune conditions like type 1 diabetes. Clinically, congenital atransferrinemia-caused by TF gene mutations-manifests as severe microcytic anemia coupled with tissue iron overload, requiring lifelong apotransferrin replacement therapy. In biotechnology, ultra-purified apotransferrin (less then0.01% iron content, 1.25 ug/mg iron-binding capacity) serves as an essential cell culture supplement, facilitating iron uptake through transferrin receptor-mediated endocytosis while preventing oxidative stress. Recent applications exploit its targeting potential in nanoparticle drug delivery systems for cancer therapeutics and as an antimicrobial adjuvant to enhance antibiotic efficacy against Gram-negative pathogens. The protein's solubility (10 mg/ml in aqueous solutions) and stability under physiological conditions enable its use in diagnostic assays and bioreactor media for biopharmaceutical production.

more then 1 year

Dog plasma was obtained from healthy animals of US origin and under the care of a registered veterinarian.

≤ -20°C

12352202