Apremilast-d8

MedChem Express

Apremilast-d8

5

Research Use Only

C22H16D8N2O7S

468.55

Apremilast-d8 (CC-10004-d8) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-alpha release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1][2].

CS(C[C@H](C1=CC(OC([2H])([2H])C([2H])([2H])[2H])=C(C=C1)OC([2H])([2H])[2H])N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)(=O)=O

12352200