APTO-253

MedChem Express

APTO-253 [916151-99-0]

10

916151-99-0

Research Use Only

98.86

C22H14FN5

367.38

APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krueppel-like factor 4 (KLF4) tumor suppressor [1] [2] . APTO-253 has antiarthritic activity [3] .

CC(N1)=C(C(N2)=NC3=C2C4=CC=CN=C4C5=NC=CC=C53)C6=C1C=CC(F)=C6

-20°C,2°C to 8°C

12352200