AR-42

MedChem Express

AR-42 [935881-37-1]

5

935881-37-1

Research Use Only

98.69

C18H20N2O3

312.36

AR-42 (HDAC-42; OSU-HDAC42) is a potent, orally bioavailable pan- HDAC inhibitor ( IC 50 =16 nM). AR-42 induces growth inhibition, cell-cycle arrest, apoptosis , and activation of caspases-3/7. AR-42 promotes hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. AR-42 shows cytotoxicity against various human cancer cell lines [1] [2] .

CC([C@@H](C1=CC=CC=C1)C(NC2=CC=C(C=C2)C(NO)=O)=O)C

-20°C,2°C to 8°C

12352200