AR-A 2

MedChem Express

AR-A 2 [220051-79-6]

10

220051-79-6

Research Use Only

C27H36N4O2

448.60

AR-A 2 is a selective 5-HT 1B receptor antagonist, with high affinity to guinea pig cortex 5HT 1B/1D and recombinant guinea pig 5-HT 1B receptors ( K i =0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT 1D receptor ( K i , 5 nM), and shows an EC 50 of 4.5 nM for the guinea pig 5-HT 1B receptor ; AR-A 2 can be used in the research of depression and anxiety.

CC1=CC=C(N2CCN(C)CC2)C3=C1CC[C@@H](NC(C4=CC=C(N5CCOCC5)C=C4)=O)C3

12352200