Western blot analysis of extracts of various cell lines using ARHGEF3 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using ARHGEF3 Polyclonal Antibody at 1:1000 dilution.
ARHGEF3 Polyclonal Antibody
E-AB-63107
Product group Antibodies
Overview
- SupplierElabscience
- Product NameARHGEF3 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionRho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- UNSPSC12352203