ARI-1

MedChem Express

ARI-1

14

Research Use Only

99.76

C20H22O7

374.38

ARI-1 is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 ( ROR1 ) inhibitor. ARI-1 effectively inhibits aberrant ROR1 expression, which is associated with the development of non-small cell lung cancer (NSCLC) and EGFR-TKI-induced drug resistance. ARI-1 binds to the extracellular Frizzled domain of ROR1 and regulates PI3K / AKT / mTOR signaling in a ROR1-dependent manner. ARI-1 potently inhibits NSCLC cell proliferation and migration and has antitumor activity in vivo [1] .

O=C1C[C@H](C2=CC=C(OC)C=C2)OC3=C1C(OCOC)=CC(OCOC)=C3

-20°C,2°C to 8°C

12352200