ARIH2 Antibody

Cusabio

ARIH2 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

ARIH2

ariadne RBR E3 ubiquitin protein ligase 2

ARI2, TRIAD1, E3 ubiquitin-protein ligase ARIH2, RING-type E3 ubiquitin transferase ARIH2, all-trans retinoic acid inducible RING finger, ariadne homolog 2, protein ariadne-2 homolog

Rabbit

IgG

E3 ubiquitin-protein ligase ARIH2

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates Lys-6, Lys-48-and Lys-63-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).

Human, Mouse

-20°C or -80°C

41116161