ARIH2 Polyclonal Antibody

Reddot Biotech

ARIH2 Polyclonal Antibody

5

Western Blot, ELISA

Research Use Only

Polyclonal

0.6 mg/ml

Unconjugated

ARIH2

ariadne RBR E3 ubiquitin protein ligase 2

ARI2, TRIAD1, E3 ubiquitin-protein ligase ARIH2, RING-type E3 ubiquitin transferase ARIH2, all-trans retinoic acid inducible RING finger, ariadne homolog 2, protein ariadne-2 homolog

Rabbit

IgG

TRIAD1, also known as ARIH2 (ariadne homolog 2) or ARI2, is a 493 amino acid protein that contains one IBR-type zinc finger and two RING-type zinc fingers and belongs to the ariadne subfamily of RBR proteins. Localized to the nucleus, TRIAD1 interacts with UBE2L3 and is thought to act as an E3 ubiquitin-protein ligase, functioning to accept ubiquitin from E2 ubiquitin-conjugating enzymes and transfer the acquired ubiquitin residue to target substrates. TRIAD1 is subject to post-translational DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding TRIAD1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

-20°C

12352203