ARN14494 [1037837-27-6]

MedChem Express

ARN14494 [1037837-27-6]

10

1037837-27-6

Research Use Only

99.08

C24H32N4O3

424.54

ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from beta-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimers disease research[1].

O=C(C1=CC2=C(N(C3CCN(CC(N4CC5C(CCC5)C4)=O)CC3)C(C2)=O)C=C1)NC

-20°C,2°C to 8°C

12352200