ARS-853

MedChem Express

ARS-853 [1629268-00-3]

10

1629268-00-3

Research Use Only

98.39

C22H29ClN4O3

432.94

ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC 50 of 2.5 microM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation [1] [2] .

ClC1=C(C2(C)CC2)C=C(NCC(N3CCN(C4CN(C(C=C)=O)C4)CC3)=O)C(O)=C1

-20°C,2°C to 8°C

12352200