ART558

MedChem Express

ART558 [2603528-97-6]

10

2603528-97-6

Research Use Only

99.97

C21H21F3N4O2

418.41

ART558 is a potent, selective and allosteric DNA polymerase theta (Poltheta) inhibitor (IC50=7.9 nM). ART558 elicits BRCA-gene synthetic lethality and DNA damage. ART558 can be used for the research of cancer, such as breast cancer[1].

CN(C1=CC(C)=CC=C1)C([C@H]2N(C3=C(C(C(F)(F)F)=CC(C)=N3)C#N)CC[C@H]2O)=O

2°C to 8°C

12352200