Articaine (hydrochloride) [23964-57-0]
HY-B0516
Overview
- SupplierMedChem Express
- Product NameArticaine (hydrochloride) [23964-57-0]
- Delivery Days Customer5
- CAS Number23964-57-0
- CertificationResearch Use Only
- Estimated Purity99.38
- Molecular FormulaC13H21ClN2O3S
- Molecular Weight320.84
- Scientific DescriptionArticaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 microM for open-state Na+ channels, and IC50 of 40.6 microM and 378 microM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-kappaB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury)[1][2][3].
- SMILESO=C(C(C)NCCC)NC(C(C)=CS1)=C1C(OC)=O.Cl
- Storage Instruction2°C to 8°C
- UNSPSC12131703