ARTS peptide

GeneTex

ARTS peptide

9

The peptide is used for blocking the activity of anit-ARTS antibody (GTX29651). Incubatingthe peptide with equal volume of antibody for 30 min at 37C usually completely blocks theactivity of anti-ARTS in Western blotting.

Neutralisation/Blocking

Research Use Only

0.20 mg/ml

Unconjugated

Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.

-20°C

12352202