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ProductsBack/ARV-393

ARV-393

ORB2647207

Molecular Weight898.42

Product group Chemicals

Overview

Supplier
Biorbyt
Product Name
ARV-393
Delivery Days Customer
10
Certification
Research Use Only
Molecular Formula
C46H53ClFN9O7
Molecular Weight
898.42
Scientific Description
ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6. ARV-393 consists of ligand conjugates targeting BCL6 and the E3 ligase cereblon, respectively. ARV-393 has DC50 and GI50 values of < 1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). ARV-393 also demonstrated considerable tumor suppressor activity in tumor xenograft models. ARV-393 is being studied to inhibit non-Hodgkin lymphoma.
SMILES
ClC1=CN=C(N2CCC(O[C@@H]3C[C@@H](N4CCC(C5=C(F)C(CN(C6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)C3)CC2)N=C1NC8=CC(C=C(OCC(NC)=O)C(N9C(C)C)=O)=C9C=C8
UNSPSC
12352200

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