ARV-825 Chemical Structure. CAS No. : 1818885-28-7
ARV-825 Chemical Structure. CAS No. : 1818885-28-7
ARV-825
HY-16954
CAS Number1818885-28-7
Product group Chemicals
Estimated Purity99.33
Molecular Weight923.43
Overview
- SupplierMedChem Express
- Product NameARV-825 [1818885-28-7]
- Delivery Days Customer10
- CAS Number1818885-28-7
- CertificationResearch Use Only
- Estimated Purity99.33
- Molecular FormulaC46H47ClN8O9S
- Molecular Weight923.43
- Scientific DescriptionARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively.
- SMILESCC1=NN=C2N1C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NC5=CC=C(OCCOCCOCCOCCNC6=C(C(N(C7CCC(NC7=O)=O)C8=O)=O)C8=CC=C6)C=C5)=O
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63.Read more