AS 1269574

AbMole BioScience

AS 1269574

9

330981-72-1

Chemical

Research Use Only

C13H14BrN3O

308.17

AS1269574 is a potent, orally active GPR119 agonist with an EC50 of 2.5 uM in HEK293 cells expressing human GPR119. AS1269574 activates the TRPA1 cation channel and stimulates glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induced pancreatic bèta cells to secrete glucose-dependent insulin only under high glucose conditions. AS1269574 has potential for type 2 diabetes research.

CC1=CC(=NC(=N1)C2=CC=C(Br)C=C2)NCCO

12352200