AS2553627 [1251906-10-1]

MedChem Express

AS2553627 [1251906-10-1]

9

1251906-10-1

Research Use Only

C18H19N5O

321.38

AS2553627 is a type of JAK inhibitor, with IC50 values of 0.46, 0.30, 0.14, and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively. AS2553627 can inhibit the proliferation of human and rat T cells stimulated by IL-2, with IC50 values of 2.4 and 4.3 nM, respectively. AS2553627 can reduce cardiac allograft vasculopathy and fibrosis in a rat heart transplant model, effectively extending survival rates. AS2553627 can be used to prevent acute and chronic rejection in heart transplants[1].

N#CCC(N1C[C@H](N2C=CC3=CN=C(NC=C4)C4=C32)[C@H](C)CC1)=O

12352200