ASAH2 Antibody

Cusabio

ASAH2 Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

ASAH2

N-acylsphingosine amidohydrolase 2

BCDase, HNAC1, LCDase, N-CDase, NCDase, neutral ceramidase, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2, acylsphingosine deacylase 2, mitochondrial ceramidase, neutral/alkaline ceramidase, non-lysosomal ceramidase

Rabbit

IgG

Neutral ceramidase

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.

Human, Rat

-20°C or -80°C

41116161