Ascomycin (high purity)

Bioss

Ascomycin (high purity)

16

Research Use Only

>98%

Macrolide antibiotic. Ethyl analog of FK506 [1, 2]. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)) [2-4, 8]. Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells [5-7]. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases [5, 6]. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions [7, 8]. Antifungal [1]. Antimalaria compound [9]. Anticonvulsant (antiepileptic) [10, 11].

-20°C

51280000