Asimadoline (hydrochloride) [185951-07-9]

MedChem Express

Asimadoline (hydrochloride) [185951-07-9]

10

185951-07-9

Research Use Only

99.82

C27H31ClN2O2

451.00

Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active kappa-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline hydrochloride ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS)[1][2][3].

O[C@H]1CCN(C1)C[C@H](C2=CC=CC=C2)N(C)C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O.[H]Cl

2°C to 8°C

12352200