Aspartoacylase antibody [N1C3-2]
GTX113389
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetASPA
Overview
- SupplierGeneTex
- Product NameAspartoacylase antibody [N1C3-2]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:5000-1:20000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.33 mg/ml
- ConjugateUnconjugated
- Gene ID443
- Target nameASPA
- Target descriptionaspartoacylase
- Target synonymsACY2, ASP, aspartoacylase, ACY-2, aminoacylase 2, cytosolic aspartoacylase
- HostRabbit
- IsotypeIgG
- Protein IDP45381
- Protein NameAspartoacylase
- Scientific DescriptionThis gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Xing YL, Poh J, Chuang BHA, et al. High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS. Cell Rep Methods. 2023,3(2):100414. doi: 10.1016/j.crmeth.2023.100414Read this paper
- Chen Y, Quan S, Patil V, et al. Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response. bioRxiv. 2023,:pii: 2023.01.23.525156. doi: 10.1101/2023.01.23.525156.Read this paper
- DeFlitch L, Gonzalez-Fernandez E, Crawley I, et al. Age and Alzheimer's Disease-Related Oligodendrocyte Changes in Hippocampal Subregions. Front Cell Neurosci. 2022,16:847097. doi: 10.3389/fncel.2022.847097Read this paper
- Lucas A, Poleg S, Klug A, et al. Myelination Deficits in the Auditory Brainstem of a Mouse Model of Fragile X Syndrome. Front Neurosci. 2021,15:772943. doi: 10.3389/fnins.2021.772943Read this paper
- Cardona HJ, Somasundaram A, Crabtree DM, et al. Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination. Brain Behav. 2021,11(10):e2332. doi: 10.1002/brb3.2332Read this paper
- Chen Y, Kunjamma RB, Weiner M, et al. Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment. Elife. 2021,10. doi: 10.7554/eLife.65469Read this paper
- Nair G, Dodd S, Ha SK, et al. Ex vivo MR microscopy of a human brain with multiple sclerosis: Visualizing individual cells in tissue using intrinsic iron. Neuroimage. 2020,223:117285. doi: 10.1016/j.neuroimage.2020.117285Read this paper
- Orthmann-Murphy J, Call CL, Molina-Castro GC, et al. Remyelination alters the pattern of myelin in the cerebral cortex. Elife. 2020,9. doi: 10.7554/eLife.56621Read this paper
- Choi BR, Cave C, Na CH, et al. GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation. Cell Rep. 2020,31(5):107540. doi: 10.1016/j.celrep.2020.107540Read this paper
- Xin W, Mironova YA, Shen H, et al. Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase. Cell Rep. 2019,27(8):2262-2271.e5. doi: 10.1016/j.celrep.2019.04.094Read this paper
Datasheet
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