AST 487

MedChem Express

AST 487 [630124-46-8]

10

630124-46-8

Research Use Only

98.90

C26H30F3N7O2

529.56

AST 487 is a RET kinase inhibitor with IC 50 of 880 nM, inhibits RET autophosphorylation and activation of downstream effectors, also inhibits Flt-3 with IC 50 of 520 nM.

O=C(NC1=CC=C(OC2=NC=NC(NC)=C2)C=C1)NC3=CC=C(CN4CCN(CC)CC4)C(C(F)(F)F)=C3

-20°C,2°C to 8°C

12352200