Asterric Acid

MedChem Express

Asterric Acid [577-64-0]

5

577-64-0

Research Use Only

C17H16O8

348.30

Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 microM.1 Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 microM, which suggests its usefulness as an antiangiogenic agent.

CC1=CC(O)=C(C(OC2=C(C=C(C=C2C(OC)=O)O)OC)=C1)C(O)=O

12352200